The CKD-REIN cohort follows 3000 patients with moderate or advanced chronic kidney disease (stage 3 or 4) in 40 nationally representative nephrology doctors’\ offices, with the following objectives:

• Studying the social, environmental and genetic factors associated with the progression of chronic kidney disease and its complications
• Identifying new predictive biomarkers of the prognosis of the disease and its complications
• Evaluating the practices and modes of care organization associated with better survival and quality of life for patients, fewer hospitalizations, and a better transition to dialysis or transplantation
• Quantifying the cost of care practices and relating them to their efficiency

CKD-REIN is coordinated with the international study, CKDopps, (CKD Outcomes and Practice Pattern Study) and contributes to the iNETCKD network (International NETwork of CKD cohorts) of the International Society of Nephrology.

• Villain C, Metzger M, Liabeuf S, Hamroun A, Laville S, Mansencal N, Combe C, Fouque D, Frimat L, Jacquelinet C, Laville M, Ayav C, Briançon S, Pecoits-Filho R, Hannedouche T, Stengel B, A. Massy ZA, on behalf of theCKD-REIN Study Group. Effectiveness and Tolerance of Renin-Angiotensin System Inhibitors with Aging in Chronic Kidney Disease. JAMDA. Published 2021 Nov 29. S1525-8610(21)00939-7. doi: 10.1016/j.jamda.2021.10.019
• Hamroun A, Frimat L, Laville M, Metzger M, Combe C, Fouque D, Jacquelinet C, Ayav C, Liabeuf S, Lange C, Herpe YE, Zee J, Glowacki F, Massy ZA, Robinson B, Stengel B, CKD-REIN  study group. New Insights into Acute-on-Chronic Kidney Disease in Nephrology Patients: The CKD-REIN Study. Nephrol Dial Transplant. Published 2021 Sep 2. gfab249. doi: 10.1093/ndt/gfab249
• Fages V, Alencar de Pinho N, Hamroun A, Lange C, Combe C, Fouque D, Frimat L, Jacquelinet C, Laville M, Ayav C, Liabeuf C, Pecoits-Filho R, Massy ZA, Boucquemont J, Stengel B, on behalf of the CKD-REIN study collaborators. Urgent dialysis start in patients early referred to a nephrologist – A prospective cohort study. Nephrol Dial Transplant 2021;36(8):1500-1510
• Laville S, Gras-Champel V, Moragny J, Metzger M, Jacquelinet C, Combe C, Fouque D, Laville M, Frimat L, Robinson BM, Stengel B, Massy ZA, Liabeuf S on behalf of the CKD-REIN Study Group. Adverse Drug Reactions in Patients with Chronic Kidney Disease – The CKD-Renal Epidemiology and Information Network cohort study. Clin J Am Soc Nephrol 2020;15(8):1090-1102
• Alencar de Pinho N, Levin A, Fukagawa M, Hoy WE, Pecoits-Filho R, Reichel H, Robinson B, Kitiyakara C, Wang J, Eckardt KU, Jha V, Oh KH, Sola L, Eder S, de Borst M, Taal M, Feldman HI, Stengel B; the International Network of Chronic Kidney Disease cohort studies (iNET-CKD). Considerable international variations exist in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney international 2019;96(4):983-994.

• Full list of publications on CKD-REIN website.
• Full list of PubMed referenced publications.

The CKD-REIN cohort is led by Bénédicte Stengel, senior investigator with Inserm (National Institute of Health and Medical Research), and head of the “Clinical Epidemiology” team with the Center for Research in Epidemiology and Health of Populations (CESP) within a consortium involving 13 academic partners. The study is coordinated by Paris-Saclay University and sponsored by Inserm.