CKD-REIN (Chronic Kidney Disease)

Cohort of patients with chronic kidney disease
CKD-Rein logo

Preserving kidney function and reducing the impact of treatments for renal failure – dialysis or transplantation – represent a challenge for clinics and public health. The national CKD-REIN cohort aims to answer key questions about the determinants of the prognosis of chronic kidney disease and the practices most likely to improve patient quality of life and life expectancy.

Key elements

  • Launched in 2013
  • 3,000 patients with chronic kidney disease
  • Follow-up until 2023

Objectives of the cohorte

The CKD-REIN cohort follows 3000 patients with moderate or advanced chronic kidney disease (stage 3 or 4) in 40 nationally representative nephrology doctors’\ offices, with the following objectives:

  • Studying the social, environmental and genetic factors associated with the progression of chronic kidney disease and its complications
  • Identifying new predictive biomarkers of the prognosis of the disease and its complications
  • Evaluating the practices and modes of care organization associated with better survival and quality of life for patients, fewer hospitalizations, and a better transition to dialysis or transplantation
  • Quantifying the cost of care practices and relating them to their efficiency

CKD-REIN is coordinated with the international study, CKDopps, (CKD Outcomes and Practice Pattern Study) and contributes to the iNETCKD network (International NETwork of CKD cohorts) of the International Society of Nephrology.

Recent publications

  • Villain C, Metzger M, Liabeuf S, Hamroun A, Laville S, Mansencal N, Combe C, Fouque D, Frimat L, Jacquelinet C, Laville M, Ayav C, Briançon S, Pecoits-Filho R, Hannedouche T, Stengel B, A. Massy ZA, on behalf of theCKD-REIN Study Group. Effectiveness and Tolerance of Renin-Angiotensin System Inhibitors with Aging in Chronic Kidney Disease. JAMDA. Published 2021 Nov 29. S1525-8610(21)00939-7. doi: 10.1016/j.jamda.2021.10.019
  • Hamroun A, Frimat L, Laville M, Metzger M, Combe C, Fouque D, Jacquelinet C, Ayav C, Liabeuf S, Lange C, Herpe YE, Zee J, Glowacki F, Massy ZA, Robinson B, Stengel B, CKD-REIN  study group. New Insights into Acute-on-Chronic Kidney Disease in Nephrology Patients: The CKD-REIN Study. Nephrol Dial Transplant. Published 2021 Sep 2. gfab249. doi: 10.1093/ndt/gfab249
  • Fages V, Alencar de Pinho N, Hamroun A, Lange C, Combe C, Fouque D, Frimat L, Jacquelinet C, Laville M, Ayav C, Liabeuf C, Pecoits-Filho R, Massy ZA, Boucquemont J, Stengel B, on behalf of the CKD-REIN study collaborators. Urgent dialysis start in patients early referred to a nephrologist – A prospective cohort study. Nephrol Dial Transplant 2021;36(8):1500-1510
  • Laville S, Gras-Champel V, Moragny J, Metzger M, Jacquelinet C, Combe C, Fouque D, Laville M, Frimat L, Robinson BM, Stengel B, Massy ZA, Liabeuf S on behalf of the CKD-REIN Study Group. Adverse Drug Reactions in Patients with Chronic Kidney Disease – The CKD-Renal Epidemiology and Information Network cohort study. Clin J Am Soc Nephrol 2020;15(8):1090-1102
  • Alencar de Pinho N, Levin A, Fukagawa M, Hoy WE, Pecoits-Filho R, Reichel H, Robinson B, Kitiyakara C, Wang J, Eckardt KU, Jha V, Oh KH, Sola L, Eder S, de Borst M, Taal M, Feldman HI, Stengel B; the International Network of Chronic Kidney Disease cohort studies (iNET-CKD). Considerable international variations exist in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney international 2019;96(4):983-994.


Management and governance

The CKD-REIN cohort is led by Bénédicte Stengel, senior investigator with Inserm (National Institute of Health and Medical Research), and head of the “Clinical Epidemiology” team with the Center for Research in Epidemiology and Health of Populations (CESP) within a consortium involving 13 academic partners. The study is coordinated by Paris-Saclay University and sponsored by Inserm.

Terms and conditions of accessing cohort data

  • The resources (data and samples) are accessible to any requesting team, public or private, according to the rules and terms of service of the CKD-REIN cohort charter 
  • To access it, contact the coordination team at the address,
  • The requesting team must submit a specific research project (PRS) to the address shown above, using a form adapted to the nature of the team, i.e., public or private.
  • The PRS is evaluated by two scientific experts and reviewed by the steering committee
  • If the PRS is accepted, the requesting team is informed and an agreement for the provision of data or samples is drawn up

Detailed information