CONSTANCES

Constances monitors 220,000 volunteers using an annual questionnaire, a health examination every 4 years and by annual matching with the old-age insurance and the national health data system (SNDS) databases. Creation of a biobank of 80,000 volunteers. A cohort of 400,000 persons is strictly representative of the eligible population followed in the administrative databases and makes it possible to study the effects of selection.

• Launched in 2012
• “Generalist” population cohort
• Representative sample of 220,000 adults affiliated with the general social security scheme, aged 18 to 69 at enrollment
• Open to the research and public health community

Constances is a tool for epidemiological research, due to its size, the particularly comprehensive nature of the system for monitoring and collecting highly diversified information, using several data sources, it is on the scale of the largest cohorts in the world.

Constances is a tool for public health and monitoring, designed to support the public health objectives of the National Health Insurance Fund (CNAM) and the State, in particular through a partnership with Santé Publique France (French Public Health Agency).

Constances is managed within the framework of the Joint Service Unit (UMS) 11, resulting from a partnership between Inserm, Paris Cité University (UPC), Paris-Saclay University (UPS), and Versailles Saint-Quentin-en-Yvelines University (UVSQ).

The Constances project is carried out thanks to the participation of Health Examination Centers, and with additional support from the National Health Insurance Fund (CNAM), the National Old Age Insurance Fund (Cnav), and the french Ministry of Health (General Directorate of Health). 

It is coordinated by Marie Zins, epidemiologist, research professor at UPC.