FILOMENE

France-Investigation LOngitudinale sur les Maladies et l’ENvironnement dans l’Enfance

FILOMENE is a nationwide pediatric cohort project in France, with prenatal recruitment, aiming to enroll 100,000 expectant parents during pregnancy and to monitor the health and development of their children into adulthood. It will establish a long-term research platform open to the scientific community, dedicated to the study of the exposome in its broadest sense (physical, chemical, biological, psychosocial, and behavioral factors, as well as endogenous factors) and its impact on health and development from the earliest stages of life. Implementing the FILOMENE cohort is part of France’s 2030 Health Innovation Plan.

Cohort Objectives

  • Characterize the role of early-life exposures on development and health throughout life
  • Investigate the biological mechanisms underlying the effects of identified risk factors
  • Address these issues among vulnerable populations (socially or medically) and in high-risk regions, thanks to the nationwide design of the cohort, including overseas departments and regions

Planned Data Collection Methodology

Contribute to the development and enrichment of data on pregnancy and pediatric health, and improve how routinely collected data is Planned Data Collection Methodology

  • Early maternal recruitment during pregnancy
  • Active collection of data and biological samples from parents and children (urine, hair, teeth, blood, umbilical cord blood, placenta, stool, etc.) during pregnancy and up to two years after birth, covering the “first 1,000 days”
  • Active, repeated collection of data and biological samples, combined with data from  national databases (the National Health Data System (SNDS), the national childhood cancer registry, other national disease registries, and regional hospital data warehouses, etc.) until early adulthood
  • This methodology is inspired by existing French cohorts. You can consult their protocols and the types of data collected here:

Tentative Schedule

  • A pilot phase will be launched in the first half of 2027 to consolidate recruitment and data collection methods
  • The second phase, starting in 2028, will focus on nationwide recruitment deployment
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at the first 1000 days most of the strategy consist in active data collection

Governance

The FILOMENE cohort is under the scientific leadership of Dr. Barbara Heude, epidemiologist and Research Director at CRESS, Inserm, and Prof. Romain Basmaci, Head of the General Pediatrics Department at Louis Mourier Hospital, in collaboration with a project team of epidemiologists and experts in mother-child cohorts.

Contact

cohorte.filomene@inserm.fr

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Logos partenaires FILOMENE

No news has been published for this cohort, you can consult all the news in the spotlight section